thecultureofme:

“Man of Steel” - “Fate of Your Planet” trailer. Holy fucking shit.

(Fonte: youtube.com)

guyalexandergriffin:

Lesson # 522 : “Architecture arouses sentiments in man. The architect’s task therefore, is to make those sentiments more precise.”
Adolf Loos

Le MAXXI by Zaha Hadid, Rome 2010

Musée national des arts du XXI^e siècle

frank0c:

I NEED IT

(Fonte: paraamanha, via mellowhigh)

bobbycaputo:

Amazing Kaleidoscopic Photos of Gaudí’s La Sagrada Família

Barcelona-based photographer Clement Celma captures magnificent perspectives of Basílica i Temple Expiatori de la Sagrada Família, a Roman Catholic church in Barcelona designed by Spanish architect Antoni Gaudí. The views from below, looking up at the meticulously detailed architecture, whose construction began over a century ago, is a breathtaking display of art nouveau.

There’s a geometric symmetry to the cathedral’s intricate design that is all the more mesmerizing from Celma’s perspective. Many of the images in the photographer’s collection are naturally kaleidoscopic, drawing the viewer’s eye to the center while keeping the senses occupied with the colors, lines, and patterns extending outward.

Gaudí’s vision for the monumental structure boasts spectacular details within every square inch of the architecture. Though the church remains incomplete, over a century since Gaudí began working on it in 1882, the site welcomes visitors to help fund the project. There is a projected completion date for 2026, in time for the centennial of Gaudí’s death, though it is only an estimation.

(via laughterkey)

neuromorphogenesis:

Reducing caloric intake delays nerve cell loss

Activating an enzyme known to play a role in the anti-aging benefits of calorie restriction delays the loss of brain cells and preserves cognitive function in mice, according to a study published in the May 22 issue of The Journal of Neuroscience. The findings could one day guide researchers to discover drug alternatives that slow the progress of age-associated impairments in the brain. 

Previous studies have shown that reducing calorie consumption extends the lifespan of a variety of species and decreases the brain changes that often accompany aging and neurodegenerative diseases such as Alzheimer’s. There is also evidence that caloric restriction activates an enzyme called Sirtuin 1 (SIRT1), which studies suggest offers some protection against age-associated impairments in the brain. 

In the current study, Li-Huei Tsai — director of the Picower Institute for Learning and Memory and Picower Professor of Neuroscience at MIT — along with postdoc Johannes Gräff and others at MIT tested whether reducing caloric intake would delay the onset of nerve cell loss that is common in neurodegenerative disease, and if so, whether SIRT1 activation was driving this effect. The group not only confirmed that caloric restriction delays nerve cell loss, but also found that a drug that activates SIRT1 produces the same effects.

“There has been great interest in finding compounds that mimic the benefits of caloric restriction that could be used to delay the onset of age-associated problems and/or diseases,” says Dr. Luigi Puglielli, who studies aging at the University of Wisconsin, Madison, and was not involved in this study. “If proven safe for humans, this study suggests such a drug could be used as a preventive tool to delay the onset of neurodegeneration associated with several diseases that affect the aging brain.”

In the study, Tsai’s team first decreased the normal diets of mice genetically engineered to rapidly undergo changes in the brain associated with neurodegeneration by 30 percent. Following three months on the diet, the mice completed several learning and memory tests. “We not only observed a delay in the onset of neurodegeneration in the calorie-restricted mice, but the animals were spared the learning and memory deficits of mice that did not consume reduced-calorie diets,” Tsai says.

Curious if they could recreate the benefits of caloric restriction without changing the animals’ diets, the scientists gave a separate group of mice a drug that activates SIRT1. Similar to what the researchers found in the mice exposed to reduced-calorie diets, the mice that received the drug had less cell loss and better cellular connectivity than the mice that did not receive the drug. Additionally, the mice that received the drug treatment performed as well as normal mice in learning and memory tests.

“The question now is whether this type of treatment will work in other animal models, whether it’s safe for use over time, and whether it only temporarily slows down the progression of neurodegeneration or stops it altogether,” Tsai says.

liamdryden:

tondalayo:

foxes enjoying themselves (x)

you’re welcome

i can’t deal with this

(via timetravellingbunny)

buckangel:

A new photo of Jimmy the mutant rescue bird

(Fonte: mauriciom97, via lustliesandlipstick)

sensacional!

(via lustliesandlipstick)

.
flickr.com

(Fonte: silencioserueda, via madamescherzo)

brit:

Quinoa might just be the new oatmeal, especially when paired with bananas and coconut milk. Get the recipe.

superseventies:

Model wearing fashion by Ossie Clark with a print by Jim Lee.

(Fonte: pinterest.com)

medicalschool:

The human brain in cross section

(via neuromorphogenesis)

anabean:

Patricinhas, encontrem o sublime || @ Casa da Matriz || 2013 || por @urbe

ifc:

Tomorrow, catch a new Buzzfeed Block, feat. City Slickers and Austin Powers: Goldmember - starting at 8/7c: http://ifc.tv/10ACmfT

(Fonte: urrectum, via klaatu)